急性弓形虫病期间人类γδ T细胞的表型特征和功能特性
Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis.
作者信息
De Paoli P, Basaglia G, Gennari D, Crovatto M, Modolo M L, Santini G
机构信息
Department of Microbiology and Immunology, General Hospital USL11, Pordenone, Italy.
出版信息
J Clin Microbiol. 1992 Mar;30(3):729-31. doi: 10.1128/jcm.30.3.729-731.1992.
Abstract
Gamma and delta (gamma delta) T-cell receptor lymphocytes are increased during acute toxoplasmosis. These cells are BB3+ CD45RO+ CD8-. Purified gamma delta T cells failed to proliferate in response to Toxoplasma gondii antigen (stimulation index, 1.4 +/- 0.6) but were responsive to phytohemagglutinin stimulation (stimulation index, 20.8 +/- 1.9). Natural-killer-like cytotoxicity was strongly acquired only after in vitro culture of purified gamma delta T cells with recombinant interleukin 2 (40% +/- 7% specific lysis). Our data show that gamma delta T-cell receptor T cells with a peculiar phenotype are increased during human acute T. gondii infection.
摘要
在急性弓形虫病期间，γδ（γ-δ）T细胞受体淋巴细胞会增加。这些细胞为BB3 + CD45RO + CD8 - 。纯化的γδT细胞对弓形虫抗原无增殖反应（刺激指数为1.4±0.6），但对植物血凝素刺激有反应（刺激指数为20.8±1.9）。只有在将纯化的γδT细胞与重组白细胞介素2进行体外培养后，才会强烈获得自然杀伤样细胞毒性（特异性裂解率为40%±7%）。我们的数据表明，在人类急性弓形虫感染期间，具有特殊表型的γδT细胞受体T细胞会增加。
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