Konrad P, Dougan P, Bergqvist D
Department of Experimental Research, University of Lund, Malmö, Sweden.
Eur J Vasc Surg. 1992 Jan;6(1):67-72. doi: 10.1016/s0950-821x(05)80097-0.
The early stages of platelet accumulation in two types of sealed interposition Dacron grafts implanted in the carotid arteries of sheep have been studied. One type was externally coated with collagen (Haemaguard) while the other experimental conduit had an additional inner lining of the same substance. 32P-labelled platelets were used to assess platelet accumulation and corrections for wall absorption were calculated. The activities in both types of grafts were highest proximally and decreased towards the distal anastomosis. The increases in the doubly-sealed grafts were larger than in those that had been single sealed, presumably reflecting activation of platelets in contact with collagen at the graft-wall and bloodstream interface. In addition, a significantly larger amount of thrombus was formed in the doubly-sealed grafts 4 h after reperfusion. It is reasonable to assume that increased acute thrombogenicity due to direct collagen-blood contact on graft surfaces is unfavourable to long term patency.
对植入绵羊颈动脉的两种密封涤纶中间移植血管中血小板聚集的早期阶段进行了研究。一种类型的血管外部涂有胶原蛋白（Hemaguard），而另一种实验性导管在内部还有一层相同物质的内衬。使用32P标记的血小板来评估血小板聚集情况，并计算壁吸收校正值。两种类型移植血管中的活性在近端最高，向远端吻合口方向降低。双重密封移植血管中的活性增加幅度大于单重密封的移植血管，这可能反映了在移植血管壁与血流界面处与胶原蛋白接触的血小板被激活。此外，再灌注4小时后，双重密封移植血管中形成的血栓量明显更多。可以合理推测，由于移植血管表面胶原蛋白与血液直接接触导致急性血栓形成增加，对长期通畅性不利。
