Brage S, Wedderkopp N, Ekelund U, Franks P W, Wareham N J, Andersen L B, Froberg K
Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Main Campus, Odense University, Odense, Denmark.
Int J Obes Relat Metab Disord. 2004 Nov;28(11):1503-8. doi: 10.1038/sj.ijo.0802772.
To explore the association between measures of insulin resistance with objectively assessed physical activity.
School-based, cross-sectional study.
A randomly selected sample of 589 children (310 girls, 279 boys, mean (standard deviations, s.d.) age=9.7 (0.44) y, weight=33.6 (6.4) kg, height=1.39 (0.06) m) from Denmark.
Fasting blood samples were analysed for serum insulin and glucose. Physical activity was measured with the uniaxial Computer Science and Applications (CSA) model 7164 accelerometer, worn for at least 3 days (>/=10 h day(-1)). Adiposity was assessed by the sum of four skinfolds. Multiple linear regression were performed to model insulin and glucose from average CSA output, adjusted for age, gender, puberty, ethnicity, birth weight, parental smoking, socioeconomic group, and CSA unit. In addition, we adjusted for skinfold thickness.
Mean fasting serum glucose ranged from 4.1 to 6.5 mmol l(-1) with a mean (s.d.) of 5.1 (0.37) mmol l(-1). Fasting insulin was negatively correlated with CSA output on levels of adjustment. Fasting glucose was not significantly associated with physical activity. However, in girls both indices of insulin resistance were significantly related to activity, whereas in boys none of the associations were significant.
Physical activity is inversely associated with fasting insulin in the nondiabetic range of fasting glucose. The relationship was stronger for insulin than for glucose, indicating compensatory action by the beta cells. Our data emphasise the importance of physical activity in children for the maintenance of metabolic control.
探讨胰岛素抵抗指标与客观评估的身体活动之间的关联。
基于学校的横断面研究。
从丹麦随机抽取的589名儿童样本（310名女孩，279名男孩，平均（标准差，s.d.）年龄 = 9.7（0.44）岁，体重 = 33.6（6.4）千克，身高 = 1.39（0.06）米）。
对空腹血样进行血清胰岛素和葡萄糖分析。使用单轴计算机科学与应用（CSA）7164型加速度计测量身体活动，佩戴至少3天（≥10小时/天）。通过四个皮褶厚度之和评估肥胖程度。进行多元线性回归，以根据平均CSA输出对胰岛素和葡萄糖进行建模，并对年龄、性别、青春期、种族、出生体重、父母吸烟情况、社会经济群体和CSA单位进行调整。此外，我们还对皮褶厚度进行了调整。
空腹血清葡萄糖均值范围为4.1至6.5毫摩尔/升，平均（s.d.）为5.1（0.37）毫摩尔/升。空腹胰岛素与调整后的CSA输出呈负相关。空腹葡萄糖与身体活动无显著关联。然而，在女孩中，胰岛素抵抗的两个指标均与活动显著相关，而在男孩中，所有关联均不显著。
在空腹血糖的非糖尿病范围内，身体活动与空腹胰岛素呈负相关。胰岛素的这种关系比葡萄糖更强，表明β细胞的代偿作用。我们的数据强调了儿童身体活动对维持代谢控制的重要性。
