压力与抑郁的最新进展：下丘脑-垂体-肾上腺（HPA）轴的作用
Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis.
作者信息
Mello Andrea de Abreu Feijó de, Mello Marcelo Feijó de, Carpenter Linda L, Price Lawrence H
机构信息
Butler Hospital, Department of Psychiatry and Human Behavior, Brown Medical School, Rhode Island, USA.
出版信息
Braz J Psychiatry. 2003 Oct;25(4):231-8. doi: 10.1590/s1516-44462003000400010. Epub 2004 Jan 15.
Abstract
Over the past 50 years, relationships between stress and the neurobiological changes seen in psychiatric disorders have been well-documented. A major focus of investigations in this area has been the role of the hypothalamic-pituitary-adrenal (HPA) axis, both as a marker of stress response and as a mediator of additional downstream pathophysiologic changes. This review examines the emerging literature concerning the relationship between stress, HPA axis function, and depression, as well as the role of early life stress as an important risk factor for HPA axis dysregulation. The more recent studies reviewed suggest that the prominence of HPA axis hyperactivity in adults with depressive and anxiety disorders may constitute a link between the occurrence of adversity in childhood and the development of adult psychopathology.
摘要
在过去50年里，压力与精神疾病中所见神经生物学变化之间的关系已有充分记录。该领域研究的一个主要焦点是下丘脑-垂体-肾上腺（HPA）轴的作用，它既是应激反应的标志物，也是其他下游病理生理变化的介导者。本文综述了有关压力、HPA轴功能与抑郁症之间关系的最新文献，以及早期生活压力作为HPA轴失调重要危险因素的作用。所综述的最新研究表明，抑郁和焦虑症成年患者中HPA轴功能亢进的突出表现可能构成童年逆境的发生与成人精神病理学发展之间的联系。
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本文引用的文献
1
Cortisol response to a combined dexamethasone-human corticotrophin-releasing hormone challenge in patients with depression.抑郁症患者联合地塞米松-人促肾上腺皮质激素释放激素刺激试验的皮质醇反应。
J Neuroendocrinol. 1989 Dec 1;1(6):485-8. doi: 10.1111/j.1365-2826.1989.tb00150.x.
2
Plasma-free corticosteroid response to electric shock in rats stimulated in infancy.幼年受刺激大鼠对电击的无血浆皮质类固醇反应。
Science. 1962 Mar 9;135(3506):795-6. doi: 10.1126/science.135.3506.795-a.
3
Hippocampal changes in patients with a first episode of major depression.首次发作的重度抑郁症患者的海马体变化。
Am J Psychiatry. 2002 Jul;159(7):1112-8. doi: 10.1176/appi.ajp.159.7.1112.
4
Stress and depression: possible links to neuron death in the hippocampus.压力与抑郁：与海马体神经元死亡的可能联系。
Bipolar Disord. 2002 Apr;4(2):117-28. doi: 10.1034/j.1399-5618.2002.01144.x.
5
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states.应激系统的组织及其在忧郁症和非典型抑郁症中的失调：高与低促肾上腺皮质激素释放激素/去甲肾上腺素状态。
Mol Psychiatry. 2002;7(3):254-75. doi: 10.1038/sj.mp.4001032.
6
Decreased corticotropin-releasing factor receptor expression and adrenocorticotropic hormone responsiveness in anterior pituitary cells of Wistar-Kyoto rats.Wistar-Kyoto大鼠垂体前叶细胞中促肾上腺皮质激素释放因子受体表达降低及促肾上腺皮质激素反应性降低。
J Neuroendocrinol. 2002 Feb;14(2):126-34. doi: 10.1046/j.0007-1331.2001.00752.x.
7
Major depression and the stress system: a life span perspective.重度抑郁症与应激系统：一种毕生视角
Dev Psychopathol. 2001 Summer;13(3):565-80. doi: 10.1017/s095457940100308x.
8
Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study.地塞米松/促肾上腺皮质激素释放激素联合试验中的皮质醇反应作为缓解期抑郁症患者复发的预测指标：一项前瞻性研究
J Psychiatr Res. 2001 Mar-Apr;35(2):83-94. doi: 10.1016/s0022-3956(01)00013-9.
9
Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse.童年期受虐成年幸存者垂体-肾上腺轴对激发性挑战试验的反应改变。
Am J Psychiatry. 2001 Apr;158(4):575-81. doi: 10.1176/appi.ajp.158.4.575.
10
Effects of adverse experiences for brain structure and function.不良经历对脑结构和功能的影响。
Biol Psychiatry. 2000 Oct 15;48(8):721-31. doi: 10.1016/s0006-3223(00)00964-1.
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