Yang Chunhua, Williams J Michael
Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA.
Org Lett. 2004 Aug 19;6(17):2837-40. doi: 10.1021/ol049621d.
A novel method for palladium-catalyzed cyanation of aryl bromides promoted by low-level tri-n-butyltin chloride or cyanide is described. The method features low catalyst loading and mild reaction conditions. KCN is used as the cyanide source. Only trace levels of the tri-n-butyltin compound are required to achieve high conversion and yield in the cyanation of aryl bromides, iodides, and triflates.
描述了一种由低水平三正丁基氯化锡或氰化物促进的钯催化芳基溴化物氰化的新方法。该方法具有催化剂负载量低和反应条件温和的特点。使用氰化钾作为氰源。在芳基溴化物、碘化物和三氟甲磺酸酯的氰化反应中，仅需痕量的三正丁基锡化合物即可实现高转化率和高收率。
