Graduate School of Education, Chung-Ang University, Seoul 06974, Korea.
Sports Medicine and Science, Global Campus, Kyung Hee University, Seoul 17104, Korea.
Int J Environ Res Public Health. 2021 Jan 19;18(2):828. doi: 10.3390/ijerph18020828.
(1) : The purpose of this meta-analysis was to investigate the effects of combined exercise and low carbohydrate ketogenic diet interventions (CELCKD) for overweight and obese individuals. (2) : Relevant studies were searched by using the MEDLINE and EMBASE databases up to October 2020. Study Inclusion and Exclusion Criteria: Inclusion criteria were reporting effects of the CELCKD for overweight and obese individuals from randomized controlled trials. Studies that did not match the inclusion criteria were excluded. The methods for CELCKD and outcomes of selected studies were extracted. The effect sizes for interventions that included cardiorespiratory fitness, body composition, fasting glucose, and lipid profiles were calculated by using the standardized mean difference statistic. (3) : A total of seven studies and 278 overweight and obese individuals were included. The average intervention of selected studies consisted of moderate to vigorous intensity, 4 times per week for 9.2 weeks. Participating in CELCKD interventions was decreased triglycerides ( = -0.34, CI; -0.68--0.01, = 0.04) and waist circumference ( = -0.74, 95% confidence interval [CI]; -1.28--1.20, = 0.01), while cardiovascular fitness, body composition, fasting glucose, total cholesterol, high density lipoprotein (HDL) cholesterol, and low density lipoprotein (LDL) cholesterol were not statistically different after the interventions. No adverse side effects were reported. (4) : Participation in interventions by overweight and obese individuals had beneficial effects including decreased waist circumference and triglycerides. Longer term intervention studies with homogenous control groups may be needed.
(1) ：本荟萃分析旨在研究联合运动和低碳水化合物生酮饮食干预（CELCKD）对超重和肥胖个体的影响。
(2) ：使用 MEDLINE 和 EMBASE 数据库检索了相关研究，检索时间截至 2020 年 10 月。研究纳入和排除标准：纳入标准为报告 CELCKD 对超重和肥胖个体的影响的随机对照试验。不符合纳入标准的研究被排除在外。提取了选定研究的 CELCKD 方法和结果。通过使用标准化均数差统计量计算了包括心肺适能、身体成分、空腹血糖和血脂谱的干预措施的效应大小。
(3) ：共纳入 7 项研究和 278 名超重和肥胖个体。选定研究的平均干预措施包括中等到剧烈强度，每周 4 次，持续 9.2 周。参与 CELCKD 干预可降低甘油三酯（ = -0.34，CI；-0.68--0.01， = 0.04）和腰围（ = -0.74，95%置信区间[CI]；-1.28--1.20， = 0.01），而心肺适能、身体成分、空腹血糖、总胆固醇、高密度脂蛋白（HDL）胆固醇和低密度脂蛋白（LDL）胆固醇在干预后无统计学差异。没有报告不良反应。
(4) ：超重和肥胖个体参与干预措施具有有益效果，包括降低腰围和甘油三酯。可能需要进行具有同质对照组的长期干预研究。
