Fv1 NB和NR嗜性的逆转录病毒衣壳决定因素。
Retroviral capsid determinants of Fv1 NB and NR tropism.
作者信息
Stevens Anthony, Bock Michael, Ellis Scott, LeTissier Paul, Bishop Kate N, Yap Melvyn W, Taylor Willie, Stoye Jonathan P
机构信息
Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
出版信息
J Virol. 2004 Sep;78(18):9592-8. doi: 10.1128/JVI.78.18.9592-9598.2004.
Abstract
The specificity determinants for susceptibility to resistance by the Fv1 n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between Fv1 and CA, we examined changes in CA resulting in the loss of susceptibility to Fv1 resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA. These amino acids may form a binding surface for Fv1.
摘要
Fv1 n和b等位基因介导的抗性易感性的特异性决定因素定位于鼠白血病病毒CA蛋白的第110位氨基酸。为了研究Fv1与CA之间的相互作用，我们检测了天然存在的嗜NB和嗜NR病毒中导致对Fv1抗性敏感性丧失的CA变化。在CA的第82、92至95、105、114和117位发现了多种影响Fv1嗜性的氨基酸变化，它们都定位于病毒体相关CA的表面。这些氨基酸可能形成Fv1的结合表面。
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