鼠白血病病毒衣壳中对小鼠Fv1和人类Ref1限制具有不同抗性调控作用的残基。
Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions.
作者信息
Lassaux Adeline, Sitbon Marc, Battini Jean-Luc
机构信息
IGMM, CNRS-UMR5535, IFR122, 1919 Rte de Mende, F-34293 Montpellier Cedex 5, France.
出版信息
J Virol. 2005 May;79(10):6560-4. doi: 10.1128/JVI.79.10.6560-6564.2005.
Abstract
We identified new residues within a 101-amino-acid stretch of the murine leukemia virus capsid that differentially modulate resistance and susceptibility to the mouse Fv1 and human Ref1 genes. Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.
摘要
我们在鼠白血病病毒衣壳的一段101个氨基酸的序列中鉴定出了新的残基，这些残基对小鼠Fv1基因和人类Ref1基因的抗性和敏感性具有不同的调节作用。在这些残基中，天冬氨酸92和组氨酸117都是Fv1(b)抗性所必需的，而后者足以赋予Ref1抗性。
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