原核生物增强子结合蛋白NTRC具有一种ATP酶活性，该活性依赖于磷酸化作用和DNA。
The prokaryotic enhancer binding protein NTRC has an ATPase activity which is phosphorylation and DNA dependent.
作者信息
Austin S, Dixon R
机构信息
AFRC-IPSR Nitrogen Fixation Laboratory, University of Sussex, Brighton, East Sussex, UK.
出版信息
EMBO J. 1992 Jun;11(6):2219-28. doi: 10.1002/j.1460-2075.1992.tb05281.x.
The prokaryotic activator protein NTRC binds to enhancer-like elements and activates transcription in response to nitrogen limitation by catalysing open complex formation by sigma 54 RNA polymerase holoenzyme. Formation of open complexes requires the phosphorylated form of NTRC and the reaction is ATP dependent. We find that NTRC has an ATPase activity which is activated by phosphorylation and is strongly stimulated by the presence of DNA containing specific NTRC binding sites.
原核激活蛋白NTRC与类增强子元件结合，并通过催化σ54 RNA聚合酶全酶形成开放复合物来响应氮限制从而激活转录。开放复合物的形成需要NTRC的磷酸化形式，并且该反应依赖于ATP。我们发现NTRC具有一种ATP酶活性，这种活性被磷酸化激活，并受到含有特定NTRC结合位点的DNA的强烈刺激。
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