羊膜的氧通透性及羊膜贴片下实际泪液氧张力

Oxygen permeability of amniotic membrane and actual tear oxygen tension beneath amniotic membrane patch.

作者信息

Yoshita Tsuyoshi, Kobayashi Akira, Sugiyama Kazuhisa, Tseng Scheffer C G

机构信息

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa-prefecture 920-8641, Japan.

出版信息

Am J Ophthalmol. 2004 Sep;138(3):486-7. doi: 10.1016/j.ajo.2004.03.021.

DOI:10.1016/j.ajo.2004.03.021

PMID:15364239

Abstract

PURPOSE

To investigate the oxygen permeability (Dk) and oxygen transmissibility (Dk/t) of amniotic membrane (AM), and tear oxygen tension beneath AM in rabbits.

DESIGN

Experimental study.

METHOD

The water content of AM was measured to calculate Dk and Dk/t, and compared with those of a therapeutic soft contact lens (TSCL). The tear oxygen tension beneath AM and TSCL was also measured in four male albino rabbits.

RESULTS

The average water content of AM was significantly higher than that of TSCL (96.8 +/- 0.8% (mean +/- SD) vs 78%, P =.0006), giving rise to a significantly higher Dk and Dk/t in AM as compared with TSCL (142.8 +/- 4.7 vs 65.3, respectively, P =.0012, and 92.9 +/- 3.0 vs 29.7, respectively, P =.0008). The average tear oxygen tension under AM was also higher than TSCL (94.9 +/- 2.9 vs 59.1 +/- 4.9 mm Hg, P =.0006).

CONCLUSIONS

These findings support the rationale of using AM as a superior bandage in treating persistent corneal epithelial defects or ulcers.

摘要

目的

研究羊膜（AM）的透氧性（Dk）和氧传导性（Dk/t），以及兔羊膜下的泪液氧分压。

设计

实验研究。

方法

测量羊膜的含水量以计算Dk和Dk/t，并与治疗性软性角膜接触镜（TSCL）进行比较。还在4只雄性白化兔中测量了羊膜和TSCL下的泪液氧分压。

结果

羊膜的平均含水量显著高于TSCL（96.8±0.8%（平均值±标准差）对78%，P = 0.0006），与TSCL相比，羊膜的Dk和Dk/t显著更高（分别为142.8±4.7对65.3，P = 0.0012，以及92.9±3.0对29.7，P = 0.0008）。羊膜下的平均泪液氧分压也高于TSCL（94.9±2.9对59.1±4.9 mmHg，P = 0.0006）。