Yigit Mehmet, Sogut Ozgur, Tataroglu Özlem, Yamanoglu Adnan, Yigit Eda, Güler Eray Metin, Ozer Omer Faruk, Kocyigit Abdurrahim
Department of Emergency Medicine, Haseki Training and Research Hospital, University of Health Sciences.
Department of Emergency Medicine, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences.
Neuropsychiatr Dis Treat. 2018 Jan 24;14:367-374. doi: 10.2147/NDT.S156710. eCollection 2018.
The present study investigated the potential roles of plasma lymphocyte DNA damage, the urotensin-2 receptor (UTS2R), and oxidative changes in patients with varying degrees of migraine-related disability who were in the ictal phase and presented to our emergency department.
This study enrolled 40 consecutive adult patients with migraine attack and 40 age- and sex-matched healthy controls. The same health care professional determined the headache-related disability of each patient's migraine attack using the Migraine Disability Assessment Scale (MIDAS); patients were divided into three groups based on MIDAS score. Plasma lymphocyte DNA damage; UTS2R, malondialdehyde (MDA), and catalase (CAT) levels; total oxidant status (TOS); total antioxidant status (TAS); and the oxidative stress index (OSI) were used as predictors of early oxidative changes.
Plasma lymphocyte DNA damage, TOS, MDA levels, and OSI values were significantly higher in patients with migraine compared to controls. Conversely, TAS and CAT and UTS2R levels were markedly lower in patients with migraine compared to controls. Comparisons of the patient groups by MIDAS score revealed significant differences in plasma lymphocyte DNA damage and CAT levels but no differences in TOS, MDA levels, OSI, TAS, or UTS2R levels. MIDAS scores were positively correlated with the degree of lymphocyte DNA damage, but neither of these factors was significantly related to CAT levels.
The present data suggest that lymphocyte DNA damage and changes in oxidative/antioxidative status may reflect an enhanced oxidative damage and an ineffective antioxidant defense system in migraineurs during headache attacks. In addition, lymphocyte DNA damage levels may be an indicator of the degree of migraine-related disability as assessed by MIDAS score.
本研究调查了处于发作期并前来我院急诊科就诊的不同程度偏头痛相关残疾患者血浆淋巴细胞DNA损伤、尾加压素-2受体（UTS2R）及氧化变化的潜在作用。
本研究纳入了40例连续的成年偏头痛发作患者及40例年龄和性别匹配的健康对照者。由同一名医护人员使用偏头痛残疾评估量表（MIDAS）确定每位患者偏头痛发作的头痛相关残疾程度；患者根据MIDAS评分分为三组。血浆淋巴细胞DNA损伤、UTS2R、丙二醛（MDA）和过氧化氢酶（CAT）水平、总氧化剂状态（TOS）、总抗氧化剂状态（TAS）及氧化应激指数（OSI）被用作早期氧化变化的预测指标。
与对照组相比，偏头痛患者的血浆淋巴细胞DNA损伤、TOS、MDA水平及OSI值显著更高。相反，与对照组相比，偏头痛患者的TAS、CAT及UTS2R水平明显更低。按MIDAS评分对患者组进行比较发现，血浆淋巴细胞DNA损伤和CAT水平存在显著差异，但TOS、MDA水平、OSI、TAS或UTS2R水平无差异。MIDAS评分与淋巴细胞DNA损伤程度呈正相关，但这两个因素均与CAT水平无显著相关性。
目前的数据表明，淋巴细胞DNA损伤以及氧化/抗氧化状态的变化可能反映了偏头痛患者在头痛发作期间氧化损伤增强及抗氧化防御系统无效。此外，淋巴细胞DNA损伤水平可能是通过MIDAS评分评估的偏头痛相关残疾程度的一个指标。
