日本的睡眠时间与死亡率：自治医科大学队列研究
Sleep duration and mortality in Japan: the Jichi Medical School Cohort Study.
作者信息
Amagai Yoko, Ishikawa Shizukiyo, Gotoh Tadao, Doi Yuriko, Kayaba Kazunori, Nakamura Yosikazu, Kajii Eiji
机构信息
Center for Community Medicine, Jichi Medical School, Minamikawachi, Tochigi 329-0498, Japan.
出版信息
J Epidemiol. 2004 Jul;14(4):124-8. doi: 10.2188/jea.14.124.
BACKGROUND
Although sleep is one of the most important health-related factors, relationship between sleep duration and mortality has not been fully discussed.
METHODS
Study subjects were 11,325 participants (4,419 males and 6,906 females) in the Jichi Medical School Cohort Study, a population-based prospective study. Baseline data were obtained by questionnaire and health checkups between April 1992 and July 1995 in 12 rural areas in Japan. Main outcome measures were all-cause and cause-specific mortality derived from death certificates up to December 31, 2001. Cox's proportional hazard models were applied to analyze the association of sleep duration with mortality.
RESULTS
A total of 495 deaths (289 males and 206 females) were observed during the average of 8.2-year follow-up period. After adjusting for age, systolic blood pressure, serum total cholesterol, body mass index, smoking habits, alcohol drinking habits, education, and marital status, the hazard ratios (95% confidence intervals) of all-cause mortality for individuals sleeping shorter than 6 hours and 9 hours or longer were 2.4 (1.3-4.2) and 1.1 (0.8-1.6) in males, and 0.7 (0.2-2.3) and 1.5 (1.0-2.4) in females, respectively, relative to those with 7-7.9 hours sleep.
CONCLUSION
Our data suggest that males with short sleep and females with long sleep were at an elevated risk of death.
背景
尽管睡眠是与健康最为重要的因素之一，但睡眠时间与死亡率之间的关系尚未得到充分探讨。
方法
研究对象为秩父 Memorial 医院队列研究中的 11325 名参与者（4419 名男性和 6906 名女性），这是一项基于人群的前瞻性研究。1992 年 4 月至 1995 年 7 月期间，通过问卷调查和健康检查在日本 12 个农村地区获取了基线数据。主要结局指标是截至 2001 年 12 月 31 日死亡证明上的全因死亡率和特定病因死亡率。应用 Cox 比例风险模型分析睡眠时间与死亡率之间的关联。
结果
在平均 8.2 年的随访期内，共观察到 495 例死亡（289 名男性和 206 名女性）。在调整年龄、收缩压、血清总胆固醇、体重指数、吸烟习惯、饮酒习惯、教育程度和婚姻状况后，睡眠时间短于 6 小时和 9 小时及以上的男性全因死亡率的风险比（95%置信区间）分别为 2.4（1.3 - 4.2）和 1.1（0.8 - 1.6），女性分别为 0.7（0.2 - 2.3）和 1.5（1.0 - 2.4），相对于睡眠时间为 7 - 7.9 小时的人群。
结论
我们的数据表明，睡眠短于 6 小时的男性和睡眠长于 9 小时的女性死亡风险升高。
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