Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
J Epidemiol. 2010;20(2):106-10. doi: 10.2188/jea.je20090053. Epub 2009 Dec 12.
Although sleep is one of the most important health-related factors, the relationship between sleep duration and the incidence of cardiovascular events has not been fully described.
The present study comprised the 11,367 study subjects (4413 men and 6954 women) of the Jichi Medical School Cohort Study, a population-based prospective study. Baseline data were obtained by questionnaire and health examinations between April 1992 and July 1995 in 12 rural areas in Japan, and the main outcome measures were the incidence of cardiovascular diseases (stroke and myocardial infarction [MI]). Cox proportional hazards models were used to analyze the association between sleep duration and the incidence of cardiovascular events.
A total of 481carciovascular events (255 men and 226 women) were observed during an average follow-up period of 10.7 years. After adjusting for age, systolic blood pressure, serum total cholesterol, body mass index, smoking habits, and alcohol drinking habits, the hazard ratios (95% confidence intervals) for the incidence of cardiovascular diseases for individuals sleeping less than 6 hours and 9 hours or longer were 2.14 (1.11-4.13) and 1.33 (0.93-1.92) in men, and 1.46 (0.70-3.04) and 1.28 (0.88-1.87) in women, respectively, relative to those who reported sleeping 7 to 7.9 hours per day.
Our data indicate that men who sleep less than 6 hours a day have a higher risk of cardiovascular events than those sleeping 7 to 7.9 hours.
尽管睡眠是与健康关系最为密切的因素之一，但睡眠时长与心血管事件发生之间的关系尚未被充分描述。
本研究纳入了日本 12 个农村地区的 11367 名研究对象（4413 名男性和 6954 名女性），这些研究对象均来自于以人群为基础的前瞻性 Jichi 医科大学队列研究。通过问卷调查和健康检查获取基线数据，时间范围为 1992 年 4 月至 1995 年 7 月。主要结局指标为心血管疾病（卒中和心肌梗死）的发生情况。采用 Cox 比例风险模型分析睡眠时长与心血管事件发生之间的关联。
在平均 10.7 年的随访期间，共观察到 481 例心血管事件（255 例男性和 226 例女性）。在校正年龄、收缩压、血清总胆固醇、体重指数、吸烟习惯和饮酒习惯后，睡眠时间少于 6 小时和 9 小时或更长的男性发生心血管疾病的风险比（95%置信区间）分别为 2.14（1.11-4.13）和 1.33（0.93-1.92），女性分别为 1.46（0.70-3.04）和 1.28（0.88-1.87），与每天睡眠时间为 7 至 7.9 小时的人相比。
我们的数据表明，每天睡眠时间少于 6 小时的男性发生心血管事件的风险高于睡眠时间为 7 至 7.9 小时的男性。
