Tidgewell Kevin, Harding Wayne W, Schmidt Mark, Holden Kenneth G, Murry Daryl J, Prisinzano Thomas E
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
Bioorg Med Chem Lett. 2004 Oct 18;14(20):5099-102. doi: 10.1016/j.bmcl.2004.07.081.
Salvinorin A is a novel hallucinogen isolated from the widely available leaves of Salvia divinorum. Based on its mechanism of action, salvinorin A has shown potential as a stimulant abuse therapeutic. However, there are no methods for the detection of salvinorin A or its metabolites in biological fluids. In order to begin developing salvinorin A as a potential therapeutic, an understanding of its metabolism is needed. Here, a straightforward synthesis of a deuterium labeled analog of salvinorin A and its utility as an internal standard for the detection of salvinorin A and its metabolites in biological fluids by LC-MS is described.
萨尔维诺林A是一种从广泛可得的鼠尾草叶中分离出的新型致幻剂。基于其作用机制，萨尔维诺林A已显示出作为兴奋剂滥用治疗药物的潜力。然而，目前尚无检测生物体液中萨尔维诺林A或其代谢物的方法。为了开始将萨尔维诺林A开发为一种潜在的治疗药物，需要了解其代谢情况。在此，描述了一种萨尔维诺林A氘代类似物的直接合成方法及其作为通过液相色谱-质谱法检测生物体液中萨尔维诺林A及其代谢物的内标的用途。
