Dai Xing, Segre Julia A
Department of Biological Chemistry, 234D Med Sci I, University of California, Irvine, California 92697-1700, USA.
Curr Opin Genet Dev. 2004 Oct;14(5):485-91. doi: 10.1016/j.gde.2004.07.002.
Recent experiments reveal the role of transcription factors in integrating upstream signals to execute specification and differentiation of epidermal cells. Based on the skin phenotype observed with misregulation of transcription factors such as p63, c-Myc, RelA, pRb, Klf4 and others, their function in controlling proliferation and differentiation is dissected. Understanding the pathways regulated by these factors and their coordinate interactions remains a challenge for the future.
近期实验揭示了转录因子在整合上游信号以执行表皮细胞的特化和分化过程中的作用。基于对转录因子（如p63、c-Myc、RelA、pRb、Klf4等）调控异常时所观察到的皮肤表型，剖析了它们在控制细胞增殖和分化中的功能。了解这些因子所调控的信号通路及其协同相互作用仍是未来面临的一项挑战。
