Greenstein V C, Holopigian K, Seiple W, Carr R E, Hood D C
Department of Ophthalmology, College of Physicians and Surgeons, Edwards S. Harkness Eye Institute, Columbia University, 635 West 165th Street, New York, NY 10032, USA.
Vision Res. 2004 Nov;44(25):2867-74. doi: 10.1016/j.visres.2004.06.020.
The purpose of this study was to investigate atypical multifocal ERG (mfERG) responses for patients with diseases that can affect the photoreceptors. MfERGS were obtained from seven patients with retinitis pigmentosa (RP), three with progressive cone dystrophy (CD) and eight with diabetic retinopathy (DR). Both first- and second-order kernel responses were analyzed. The amplitudes and implicit times of the first-order responses were compared to those obtained from age-similar controls. For the first slice of the second-order response, the root-mean-square (RMS) and the signal-to-noise ratio (SNR) of each response were calculated. Achromatic visual fields were also obtained from each subject. For the three groups of patients, first-order responses with relatively large amplitudes, broad-shaped waveforms and markedly increased implicit times had non-measurable second-order responses. These responses were associated with areas of decreased visual field sensitivity. As RP, CD and DR affect the outer retina, the results are consistent with damage to the outer plexiform layer rather than damage to the inner retina.
本研究的目的是调查患有可影响光感受器疾病的患者的非典型多焦视网膜电图（mfERG）反应。mfERG检查取自7例视网膜色素变性（RP）患者、3例进行性视锥细胞营养不良（CD）患者和8例糖尿病视网膜病变（DR）患者。对一阶和二阶核反应均进行了分析。将一阶反应的振幅和隐含时间与年龄相仿的对照组所得结果进行比较。对于二阶反应的第一切片，计算每个反应的均方根（RMS）和信噪比（SNR）。还从每个受试者获取了消色差视野。对于三组患者，具有相对较大振幅、宽波形和明显增加的隐含时间的一阶反应具有不可测量的二阶反应。这些反应与视野敏感度降低的区域相关。由于RP、CD和DR会影响视网膜外层，结果与外网状层受损而非视网膜内层受损一致。
