来自海洋红树林白骨壤的新型二萜类化合物。

New diterpenoids from the marine mangrove Bruguiera gymnorrhiza.

作者信息

Han Li, Huang Xueshi, Sattler Isabel, Dahse Hans-Martin, Fu Hongzheng, Lin Wenhan, Grabley Susanne

机构信息

National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.

出版信息

J Nat Prod. 2004 Sep;67(9):1620-3. doi: 10.1021/np040062t.

DOI:10.1021/np040062t

PMID:15387677

Abstract

Phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded three new ent-kaurane diterpenoids (1, 2, and 3) and one new ent-beyerane diterpenoid (4) together with nine known ent-kaurane diterpenoids. All structures and the relative stereochemistry of the new compounds were determined by NMR spectroscopic studies. The absolute stereochemistry of 4 was determined by CD data. Some of the compounds showed moderate cytotoxic properties.

摘要

对木榄茎进行植物化学研究，得到了三种新的对映-贝壳杉烷二萜（1、2和3）和一种新的对映-贝叶烷二萜（4），以及九种已知的对映-贝壳杉烷二萜。通过核磁共振光谱研究确定了所有新化合物的结构和相对立体化学。通过圆二色光谱数据确定了4的绝对立体化学。其中一些化合物表现出中等的细胞毒性。