链霉菌产生的新型多烯羧酸

Novel polyene carboxylic acids from Streptomyces.

作者信息

Wenzel Silke C, Bode Helge B

机构信息

Pharmazeutische Biotechnologie, Universität des Saarlandes, Gebäude 8.1, D-66123 Saarbrücken, Germany.

出版信息

J Nat Prod. 2004 Sep;67(9):1631-3. doi: 10.1021/np049852t.

DOI:10.1021/np049852t

PMID:15387680

Abstract

Reinvestigation of the production of the unusual polyene carboxylic acid serpentene (1a) from Streptomycessp. Tü 3851 revealed the presence of additional polyene carboxylic acids. The methyl esters of the new all-trans serpentene (2) and four new dicarboxylic acids (3-6) were isolated after methylation of the isolated polyene fraction. The dicarboxylic acids might result from omega- and beta-oxidation of the parent compounds 1 and 2.

摘要

对链霉菌属菌株Tü 3851产生的不寻常多烯羧酸蛇形菌素（1a）的重新研究揭示了其他多烯羧酸的存在。在分离的多烯组分甲基化后，分离出了新的全反式蛇形菌素（2）的甲酯和四种新的二羧酸（3 - 6）。二羧酸可能是母体化合物1和2经ω-氧化和β-氧化产生的。