Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA.
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.
Mar Drugs. 2014 Feb 14;12(2):1013-22. doi: 10.3390/md12021013.
Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-¹³C glucose, and analysis of a ¹³C-¹³C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
从海洋放线菌 Solwaraspora sp. 中分离得到两种新型三烷基取代芳香酸，即 solwaric 酸 A 和 B。Solwaric 酸 A 和 B 用 U-¹³C 葡萄糖进行同位素标记，¹³C-¹³C COSY 分析可明确确定苯甲基的位置。这两种新型化合物对耐甲氧西林金黄色葡萄球菌 (MRSA) 和甲氧西林敏感金黄色葡萄球菌 (MSSA) 表现出抗菌活性。
