Laker M F, Reckless J P, Betteridge D J, Durrington P N, Miller J P, Nicholls D P, Shepherd J, Thompson G R
Department of Clinical Biochemistry and Metabolic Medicine, University of Newcastle upon Tyne.
J Clin Pathol. 1992 Feb;45(2):102-5. doi: 10.1136/jcp.45.2.102.
To determine the availability of facilities for the investigation of hyperlipidaemia in the United Kingdom.
A questionnaire was sent to all health districts in the United Kingdom.
The response rate was 81%. All laboratories used enzymatic techniques to measure serum triglyceride and cholesterol concentrations, although there were differences in standardisation procedures. Reference ranges for serum lipids were quoted by 58% of laboratories while 50% quoted "desirable limits". Almost half specified that fasting blood samples were required. High density lipoprotein cholesterol concentrations were estimated by 75% and apolipoproteins AI and B by 14% of laboratories; there were differences in specimen type and considerable diversity in procedures used for measurement.
Many laboratories were unaware of current recommendations for screening for hypercholesterolaemia in the community. The present survey indicated an urgent need for the introduction of better reference methods, standardisation, and quality assurance procedures before apolipoproteins become a routine part of coronary heart disease risk assessment.
确定英国高脂血症调查设施的可获得性。
向英国所有卫生区发送了一份调查问卷。
回复率为81%。所有实验室均采用酶法技术测定血清甘油三酯和胆固醇浓度，尽管标准化程序存在差异。58%的实验室引用了血脂的参考范围，而50%的实验室引用了“理想限度”。几乎一半的实验室明确表示需要空腹血样。75%的实验室估计了高密度脂蛋白胆固醇浓度，14%的实验室估计了载脂蛋白AI和B；样本类型存在差异，测量所用程序也有很大差异。
许多实验室并不了解目前社区高胆固醇血症筛查的建议。本次调查表明，在载脂蛋白成为冠心病风险评估的常规部分之前，迫切需要引入更好的参考方法、标准化和质量保证程序。
