Davison A M, McKinney P A, Bailey C C, Lewis I, Cartwright R A, O'Brien C
University Department of Pathology, Leeds General Infirmary.
J Clin Pathol. 1992 Feb;45(2):130-4. doi: 10.1136/jcp.45.2.130.
A histopathological review of 43 cases of childhood non-Hodgkin's lymphoma (NHL) in an attempt to identify histological variables of prognostic importance.
Each case was reclassified according to the Working Formulation and an attempt made to allocate an immunophenotype using a panel of monoclonal antibodies. Results were correlated with clinical data on site and survival.
Of the 43 cases, 30 were males and 13 females. There were 17 cases of lymphoblastic lymphoma, 15 cases of small non-cleaved cell lymphoma (SNCC), and four cases of large cell lymphoma. The SNCC group was subdivided into 10 cases of Burkitt's lymphoma and five cases of non-Burkitt's lymphoma. An immunophenotype was allocated in 65.1% of cases (23 B, 5 T). The SNCC cases were spread throughout the 0-16 year age range while the lymphoblastic lymphoma cases tended to occur in older children. Most mediastinal tumours were lymphoblastic lymphoma and most abdominal tumours were SNCC. Statistical analysis failed to show a significant difference in survival among histological subgroups or immunophenotypes.
No histological variables of prognostic importance were identified partly due to the great variation in treatment regimens, standard of supportive care, and prognosis over the period of the study (1972 to 1988).
对43例儿童非霍奇金淋巴瘤（NHL）进行组织病理学回顾，以确定具有预后重要性的组织学变量。
根据工作分类法对每例病例重新分类，并尝试使用一组单克隆抗体确定免疫表型。结果与关于发病部位和生存情况的临床数据相关联。
43例病例中，男性30例，女性13例。有17例淋巴母细胞淋巴瘤，15例小无裂细胞淋巴瘤（SNCC），4例大细胞淋巴瘤。SNCC组又分为10例伯基特淋巴瘤和5例非伯基特淋巴瘤。65.1%的病例（23例B细胞型，5例T细胞型）确定了免疫表型。SNCC病例分布在0至16岁年龄范围内，而淋巴母细胞淋巴瘤病例倾向于发生在年龄较大的儿童中。大多数纵隔肿瘤是淋巴母细胞淋巴瘤，大多数腹部肿瘤是SNCC。统计分析未能显示组织学亚组或免疫表型之间在生存方面有显著差异。
未发现具有预后重要性的组织学变量，部分原因是在研究期间（1972年至1988年）治疗方案、支持治疗标准和预后存在很大差异。
