Warchoł T, Karoń H, Flieger S, Sarnowska I
Zahn Mund Kieferheilkd Zentralbl. 1978;66(8):825-8.
The activity of glucose-6-phosphate dehydrogenase and the glutathione content of red blood corpuscles were determined in twenty-five patients with tumors (of which nineteen were malignant and six, nonmalignant) as well as in a control group of twelve normal subjects. The activity of glucose-6-phosphate dehydrogenase was markedly higher in all of the tumor patients than it was in the controls. Also, the activity of glucose-6-phosphate dehydrogenase was found to increase with the time of existence of an untreated tumor.--Increased glutathione contents were determined especially in the early stages of tumor development. In patients with a relatively long record of malignant and nonmalignant tumorous diseases as well as in normal subjects there was observed no or only an inconsiderable increase in the content of glutathione.--This method of examination is assuming considerable importance for the differential diagnosis of tumors located in the maxillofacial region.
测定了25例肿瘤患者（其中19例为恶性肿瘤，6例为非恶性肿瘤）以及12名正常受试者组成的对照组红细胞中葡萄糖-6-磷酸脱氢酶的活性和谷胱甘肽含量。所有肿瘤患者体内葡萄糖-6-磷酸脱氢酶的活性均显著高于对照组。此外，还发现葡萄糖-6-磷酸脱氢酶的活性随未治疗肿瘤存在时间的延长而增加。尤其是在肿瘤发展的早期阶段，谷胱甘肽含量有所增加。在患有恶性和非恶性肿瘤疾病时间相对较长的患者以及正常受试者中，谷胱甘肽含量未出现增加或仅出现微不足道的增加。这种检查方法在颌面部肿瘤的鉴别诊断中具有相当重要的意义。
