Miles S A, Martínez-Maza O, Rezai A, Magpantay L, Kishimoto T, Nakamura S, Radka S F, Linsley P S
UCLA AIDS Center 90024.
Science. 1992 Mar 13;255(5050):1432-4. doi: 10.1126/science.1542793.
Oncostatin M, a cytokine produced by activated lymphoid cells, regulates the growth and differentiation of a number of tumor and normal cells. In contrast to its effects on normal endothelial and aortic smooth muscle cell cultures, Oncostatin M was a potent mitogen for cells derived from acquired immunodeficiency syndrome-related Kaposi's sarcoma (AIDS-KS). After exposure to Oncostatin M, AIDS-KS cells assumed a spindle morphology, had an increased ability to proliferate in soft agar, and secreted increased amounts of interleukin-6. Oncostatin M RNA and immunoreactive Oncostatin M protein were found in AIDS-KS-derived cell isolates. These results suggest that Oncostatin M may play a role in the pathogenesis of AIDS-KS.
抑瘤素M是一种由活化淋巴细胞产生的细胞因子，可调节多种肿瘤细胞和正常细胞的生长与分化。与它对正常内皮细胞和主动脉平滑肌细胞培养的作用相反，抑瘤素M是获得性免疫缺陷综合征相关卡波西肉瘤（AIDS-KS）来源细胞的强效促有丝分裂原。暴露于抑瘤素M后，AIDS-KS细胞呈现梭形形态，在软琼脂中的增殖能力增强，并分泌更多的白细胞介素-6。在AIDS-KS来源的细胞分离物中发现了抑瘤素M RNA和具有免疫反应性的抑瘤素M蛋白。这些结果表明，抑瘤素M可能在AIDS-KS的发病机制中起作用。
