251 Airforce General Hospital, Kanellopoulou 3, 11525, Athens, Greece.
Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Curr Obes Rep. 2018 Dec;7(4):260-275. doi: 10.1007/s13679-018-0318-7.
In this review, we investigate the role of classic and novel adipocytokines in cancer pathogenesis synopsizing the mechanisms underlying the association between adipocytokines and malignancy. Special emphasis is given on novel adipocytokines as new evidence is emerging regarding their entanglement in neoplastic development.
Recent data have emphasized the role of the triad of overweight/obesity, insulin resistance and adipocytokines in cancer. In the setting of obesity, classic and novel adipocytokines present independent and joint effects on activation of major intracellular signaling pathways implicated in cell proliferation, expansion, survival, adhesion, invasion, and metastasis. Until now, more than 15 adipocytokines have been associated with cancer, and this list continues to expand. While the plethora of circulating pro-inflammatory adipocytokines, such as leptin, resistin, extracellular nicotinamide phosphoribosyl transferase, and chemerin are elevated in malignancies, some adipocytokines such as adiponectin and omentin-1 are generally decreased in cancers and are considered protective against carcinogenesis. Elucidating the intertwining of inflammation, cellular bioenergetics, and adiposopathy is significant for the development of preventive, diagnostic, and therapeutic strategies against cancer. Novel more effective and safe adipocytokine-centered therapeutic interventions may pave the way for targeted oncotherapy.
在这篇综述中，我们研究了经典和新型脂肪细胞因子在癌症发病机制中的作用，综合了脂肪细胞因子与恶性肿瘤之间关联的潜在机制。特别强调了新型脂肪细胞因子，因为关于它们在肿瘤发生发展中的作用有新的证据出现。
最近的数据强调了超重/肥胖、胰岛素抵抗和脂肪细胞因子三联征在癌症中的作用。在肥胖的情况下，经典和新型脂肪细胞因子对涉及细胞增殖、扩增、存活、黏附、侵袭和转移的主要细胞内信号通路的激活具有独立和联合作用。迄今为止，已有 15 多种脂肪细胞因子与癌症相关，而且这个列表还在不断扩大。虽然大量循环的促炎脂肪细胞因子，如瘦素、抵抗素、细胞外烟酰胺磷酸核糖转移酶和趋化素，在恶性肿瘤中升高，但一些脂肪细胞因子，如脂联素和网膜素-1，在癌症中通常降低，被认为可预防致癌作用。阐明炎症、细胞生物能学和脂肪病之间的交织关系，对于制定预防、诊断和治疗癌症的策略具有重要意义。新型更有效和安全的以脂肪细胞因子为中心的治疗干预措施可能为靶向肿瘤治疗铺平道路。
