Corazza G R, Benati G, Sorge M, Strocchi A, Calza G, Gasbarrini G
Department of Medical Pathology, S. Orsola University Hospital, University of Bologna, Italy.
Aliment Pharmacol Ther. 1992 Feb;6(1):61-6. doi: 10.1111/j.1365-2036.1992.tb00545.x.
An assessment was made of the efficacy of a beta-galactosidase, obtained from Aspergillus niger and added to intact milk, in decreasing lactose malabsorption and intolerance. Sixteen adult patients with malabsorption and intolerance to this sugar were studied in a double-blind crossover study vs. placebo. A 5-hour hydrogen breath test was used to assess malabsorption of lactose contained in 400 ml milk. When compared with placebo, the addition of exogenous lactase to intact milk caused a statistically significant reduction in the maximum breath H2 concentration (P less than 0.01) and in the cumulative H2 excretion (P less than 0.005). In the same way, the cumulative index for gastrointestinal intolerance was significantly lower (P less than 0.005) after the ingestion of lactase-added milk. This study demonstrates that enzyme replacement therapy, with beta-galactosidases obtained from Aspergillus niger, is effective in decreasing lactose malabsorption and its consequent intolerance in adult subjects with lactase deficiency.
对从黑曲霉中提取并添加到纯牛奶中的β-半乳糖苷酶在降低乳糖吸收不良和不耐受方面的功效进行了评估。在一项双盲交叉研究中，将16名对这种糖吸收不良和不耐受的成年患者与安慰剂进行了对比研究。采用5小时呼气氢试验来评估400毫升牛奶中乳糖的吸收不良情况。与安慰剂相比，向纯牛奶中添加外源性乳糖酶可使呼气中氢气的最大浓度（P<0.01）和氢气的累积排泄量（P<0.005）在统计学上显著降低。同样，摄入添加乳糖酶的牛奶后，胃肠道不耐受的累积指数也显著降低（P<0.005）。这项研究表明，用从黑曲霉中获得的β-半乳糖苷酶进行酶替代疗法，对于降低乳糖酶缺乏的成年受试者的乳糖吸收不良及其随之而来的不耐受是有效的。
