Shigesawa T, Sato C, Marumo F
Second Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Japan.
J Gastroenterol Hepatol. 1992 Jan-Feb;7(1):7-11. doi: 10.1111/j.1440-1746.1992.tb00926.x.
Plasma glutathione levels were determined in 79 patients with various types of liver disease and 18 healthy controls in order to study their significance in the course of liver disease. Plasma was taken at the time of needle liver biopsy. A positive linear correlation was found between plasma and hepatic glutathione concentrations, as has been suggested in experimental animals. In patients with acute viral hepatitis, chronic hepatitis, non-alcoholic liver cirrhosis and alcoholic liver disease, plasma glutathione levels were significantly decreased compared with those in controls. Of importance is the fact that the plasma levels increased after recovery in patients with acute viral hepatitis and after abstinence from alcohol intake in patients with alcoholic liver disease. Determination of plasma glutathione may be valuable in the evaluation of liver disease, particularly in acute viral hepatitis and alcoholic liver disease in which the hepatic content of glutathione is suggested to be decreased. Such patients may be susceptible to oxidative stress and radical-related hepatic injury.
为研究血浆谷胱甘肽水平在肝病病程中的意义，对79例各种类型肝病患者及18名健康对照者进行了测定。血浆于经皮肝穿刺活检时采集。正如在实验动物中所提示的，血浆与肝脏谷胱甘肽浓度之间呈正线性相关。急性病毒性肝炎、慢性肝炎、非酒精性肝硬化及酒精性肝病患者的血浆谷胱甘肽水平与对照组相比显著降低。重要的是，急性病毒性肝炎患者康复后及酒精性肝病患者戒酒血浆水平升高。测定血浆谷胱甘肽对肝病评估可能有价值，尤其在急性病毒性肝炎和酒精性肝病中，提示肝脏谷胱甘肽含量降低。这类患者可能易受氧化应激及自由基相关肝损伤影响。
