Wechsung E, Houvenaghel A
Laboratory of Veterinary Physiology, University Centre of Antwerp, Belgium.
Zentralbl Veterinarmed A. 1992 Oct;39(8):561-7. doi: 10.1111/j.1439-0442.1992.tb00218.x.
In conscious piglets with electrodes implanted in the wall of the antrum pylori, the small intestine and the caecum, the influence of intravenous infusion of substance P (SP) (0.1 and 1 micrograms/kg/min for 2 hours) on gastrointestinal myoelectrical activity and arterial pressure was studied. SP was without significant influence on electrical activity of the antrum. However, intestinal myoelectrical activities were significantly stimulated. In the small intestine SP infusion resulted in an increase in frequency of migrating myoelectrical complexes and in irregular spiking activity, resulting in an augmentation of the integrated total activity. In the caecum SP provoked a prolongation of complexes of long spike bursts (LSB) as well as an increase in number of LSB/complex. In the studied doses SP had no significant effect on arterial pressure.
在已将电极植入幽门窦壁、小肠和盲肠的清醒仔猪中，研究了静脉输注P物质（SP）（0.1和1微克/千克/分钟，持续2小时）对胃肠肌电活动和动脉血压的影响。SP对胃窦电活动无显著影响。然而，肠道肌电活动受到显著刺激。在小肠中，输注SP导致移行性肌电复合波频率增加和不规则尖峰活动增加，从而使综合总活动增强。在盲肠中，SP引起长尖峰爆发（LSB）复合体延长以及每个复合体中LSB数量增加。在所研究的剂量下，SP对动脉血压无显著影响。
