De Saedeleer V, Wechsung E, Houvenaghel A
Laboratory of Veterinary Physiology, State University, Antwerp, Belgium.
Prostaglandins Leukot Essent Fatty Acids. 1992 Jan;45(1):67-70. doi: 10.1016/0952-3278(92)90104-q.
In 5 conscious piglets with electrodes implanted on the antrum pylori and small intestine, phasic and integrated electrical activity was daily recorded. PGE2, 10 micrograms/kg/min, was infused intravenously during 1.5 h and the induced changes in electrical activity were analyzed. Clinical appearance was also studied. PGE2 induced an inhibition in both antral and intestinal activity. In the antrum this inhibition was characterized by a decrease in the frequency of electrical control activity and fast oscillations, and an increase in the duration of the inhibitory phase. Small intestinal recordings revealed an increase in the quiescence phase for the duodenum and a decrease in the integrated total activity for the duodenum, jejunum and ileum, induced by a decrease in phase II activity. PGE2 was without influence on phase III activity and the recycling of the migrating myoelectrical complexes. All piglets developed a severe diarrhea. Vomiting, sedation, fever and shivering were observed in most animals. These data suggest that the diarrheogenic effect of PGE2 is not provoked by an increase in small intestinal motility. Moreover, the direct effect of this PG is a partial inhibition of gastrointestinal electrical activity.
在5只将电极植入幽门窦和小肠的清醒仔猪中，每天记录其阶段性和综合性电活动。以10微克/千克/分钟的剂量静脉输注前列腺素E2（PGE2）1.5小时，并分析由此引起的电活动变化。同时也研究了临床表现。PGE2可抑制胃窦和肠道活动。在胃窦，这种抑制表现为电控制活动和快速振荡频率降低，抑制期持续时间延长。小肠记录显示，十二指肠静止期延长，十二指肠、空肠和回肠的综合总活动因II期活动减少而降低。PGE2对III期活动和移行性肌电复合波的循环没有影响。所有仔猪均出现严重腹泻。大多数动物出现呕吐、镇静、发热和颤抖。这些数据表明，PGE2的致腹泻作用并非由小肠运动增加引起。此外，这种前列腺素的直接作用是部分抑制胃肠电活动。
