Halloran M E, Struchiner C J
Division of Biostatistics, Emory University School of Public Health, 1599 Clifton Road NE, Atlanta, GA 30329, USA.
Parasitol Today. 1992 Mar;8(3):77-85. doi: 10.1016/0169-4758(92)90240-3.
Population effects of malaria vaccination programs will depend on a complex interaction of the stage specificity of the vaccine, its duration of effectiveness, whether it is responsive to natural boosting, the strategy implemented, the proportion vaccinated and the pre-existing endemic conditions. In this article, Elizabeth Halloran and Claudio Struchiner review models of malaria transmission that incorporate aspects of immunity relevant to studying the effects of stage-specific malaria vaccination programs. They discuss the difference in the assumptions and applicability of the models and compare their predictions. Experience with malaria has demonstrated the difficulty in eliminating transmission, so emphasis needs to be on the new host-parasite balance that will be induced by the vaccination program. Although Halloran and Struchiner advise caution in interpreting the results of such models, they conclude that quantitative and theoretical analysis will be important in planning and evaluating interventions with malaria vaccines.
疟疾疫苗接种计划对人群的影响将取决于疫苗的阶段特异性、有效性持续时间、是否对自然增强有反应、实施的策略、接种比例以及现有的流行状况等复杂的相互作用。在本文中，伊丽莎白·哈洛伦和克劳迪奥·斯特鲁希纳回顾了疟疾传播模型，这些模型纳入了与研究阶段特异性疟疾疫苗接种计划效果相关的免疫方面。他们讨论了模型假设和适用性的差异，并比较了它们的预测结果。疟疾防治经验表明消除传播存在困难，因此需要强调疫苗接种计划将引发的新的宿主 - 寄生虫平衡。尽管哈洛伦和斯特鲁希纳建议在解释此类模型的结果时要谨慎，但他们得出结论，定量和理论分析对于规划和评估疟疾疫苗干预措施将具有重要意义。
