Colombo Paul J
Department of Psychology, Tulane University, 6823 Saint Charles Avenue, New Orleans, LA, USA.
Neurobiol Learn Mem. 2004 Nov;82(3):268-77. doi: 10.1016/j.nlm.2004.07.005.
Experimental evidence for multiple memory systems grew initially from reports that integrity of the medial temporal lobes is necessary for some, but not all, types of memory formation. A primary inference from many studies of multiple memory systems is that they operate independently during encoding, storage, and retrieval of information. An accumulation of recent evidence, however, suggests that multiple memory systems may interact under some conditions. At the cellular level of analysis, it is accepted widely that protein synthesis is necessary for the formation of long-term memory and recent efforts have focused on the mechanisms by which learning-induced gene transcription and translation are regulated. The present review examines learning-induced activation of transcription factors among multiple memory systems. The results indicate that studies of transcriptional regulation, in conjunction with other experimental approaches, can provide complementary lines of evidence to further understanding of the extent to which multiple memory systems are independent or interactive.
多个记忆系统的实验证据最初源于一些报告，这些报告指出内侧颞叶的完整性对于某些（而非所有）类型的记忆形成是必要的。对多个记忆系统的许多研究的一个主要推论是，它们在信息编码、存储和检索过程中独立运作。然而，最近积累的证据表明，多个记忆系统可能在某些条件下相互作用。在细胞分析层面，人们普遍认为蛋白质合成对于长期记忆的形成是必要的，并且最近的研究工作集中在学习诱导的基因转录和翻译的调控机制上。本综述探讨了多个记忆系统中学习诱导的转录因子激活情况。结果表明，转录调控研究与其他实验方法相结合，可以提供补充性的证据线索，以进一步理解多个记忆系统在多大程度上是独立的或相互作用的。
