Gill Thomas M, Allore Heather, Holford Theodore R, Guo Zhenchao
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Am J Med. 2004 Oct 1;117(7):484-91. doi: 10.1016/j.amjmed.2004.05.018.
To determine how often disability in essential activities of daily living develops insidiously, and to evaluate whether the likelihood of insidious disability differs on the basis of physical frailty.
We conducted a prospective study of 754 nondisabled, community-living persons aged 70 years or older. Participants were categorized according to the presence or absence of physical frailty, which was defined on the basis of gait speed. Participants were subsequently followed with monthly telephone interviews for 3 years to determine the occurrence of disability in bathing, dressing, walking, or transferring, and to ascertain exposure to precipitating events, which included acute hospital admissions and other illnesses, injuries, or problems leading to restricted activity.
For first episodes of disability, 73 (36%) of 203 developed insidiously among the 322 participants who were physically frail and 26 (18%) of 141 developed insidiously among the 432 participants who were not physically frail (P <0.001). Physical frailty was the only factor that was associated significantly with the development of insidious disability, with an adjusted odds ratio of 2.4 (95% confidence interval: 1.4 to 4.1). The likelihood that an episode of disability was insidious increased progressively, from 29% of the 344 first episodes to 65% of the 155 fourth or higher episodes (P for trend <0.001).
Disability in essential activities of daily living often occurs insidiously, particularly among older persons who are physically frail or who have had prior episodes of disability.
确定日常生活基本活动能力的残疾情况有多频繁地隐匿发展,并评估隐匿性残疾的可能性是否因身体虚弱程度而异。
我们对754名70岁及以上、居住在社区且无残疾的人群进行了一项前瞻性研究。根据是否存在身体虚弱对参与者进行分类,身体虚弱根据步速定义。随后对参与者进行为期3年的每月电话随访,以确定洗澡、穿衣、行走或转移方面残疾的发生情况,并确定是否暴露于促发事件,促发事件包括急性住院以及其他导致活动受限的疾病、损伤或问题。
对于残疾的首发情况,在322名身体虚弱的参与者中,203例中有73例(36%)隐匿性发展;在432名非身体虚弱的参与者中,141例中有26例(18%)隐匿性发展(P<0.001)。身体虚弱是与隐匿性残疾发展显著相关的唯一因素,调整后的优势比为2.4(95%置信区间:1.4至4.1)。残疾发作隐匿的可能性逐渐增加,从344例首发情况中的29%增至155例第四次或更高次发作情况中的65%(趋势P<0.001)。
日常生活基本活动能力的残疾常常隐匿发生,尤其是在身体虚弱或既往有残疾发作的老年人中。