Rodríguez Yanik, Christophe Armand B
Department of Physiology and Biochemistry, Institute of Nutrition and Food Hygiene, Havana, Cuba.
Ann Nutr Metab. 2004 Sep-Oct;48(5):335-42. doi: 10.1159/000081201. Epub 2004 Oct 1.
The aim of the present study was to determine how the fatty acid composition of plasma and erythrocyte phospholipids is influenced by the diabetic condition and by dietary or glibenclamide treatment in type 2 diabetes.
The fatty acid composition of plasma and erythrocyte phospholipids is assessed in 3 nonobese groups of Cuban diabetics with comparable age and BMI: 13 newly diagnosed, 15 on diet alone and 15 on diet/glibenclamide. Thirteen healthy individuals were used as controls. Fasting serum glucose, insulin and glycosylated hemoglobin and dietary fat intake were assessed.
In plasma phospholipids, significant lower values were found for 14:0, 15:0 and 17:0 in newly diagnosed patients than in controls. In red blood cell phospholipids, 14:1, 20:0 and 24:1 of newly diagnosed patients were significantly lower than of controls, and 16:1omega7 and 18:4omega3 were significantly higher. The different treatments had an effect on 18:0, 18:1t, 20:0 and total trans fatty acids in erythrocyte, but not in plasma phospholipids.
Changes in plasma phospholipid fatty acids found in type 2 diabetics may be due to an 'adapted' dietary pattern, whereas those in erythrocyte phospholipids may be attributed to effects of the disease itself and may be susceptible to normalization by diet or glibenclamide.
本研究旨在确定2型糖尿病患者血浆和红细胞磷脂的脂肪酸组成如何受到糖尿病病情以及饮食或格列本脲治疗的影响。
对3组年龄和体重指数（BMI）相当的非肥胖古巴糖尿病患者的血浆和红细胞磷脂脂肪酸组成进行评估：13例新诊断患者、15例仅接受饮食治疗的患者和15例接受饮食/格列本脲治疗的患者。选取13名健康个体作为对照。评估空腹血糖、胰岛素、糖化血红蛋白和饮食脂肪摄入量。
在血浆磷脂中，新诊断患者的14:0、15:0和17:0含量显著低于对照组。在红细胞磷脂中，新诊断患者的14:1、20:0和24:1显著低于对照组，而16:1ω7和18:4ω3显著高于对照组。不同治疗方法对红细胞中的18:0、18:1t、20:0和总反式脂肪酸有影响，但对血浆磷脂无影响。
2型糖尿病患者血浆磷脂脂肪酸的变化可能归因于“适应性”饮食模式，而红细胞磷脂脂肪酸的变化可能归因于疾病本身的影响，并且可能通过饮食或格列本脲治疗恢复正常。
