Dominguez Delfina C
College of Health Sciences, The University of Texas at El Paso, El Paso, TX 79902, USA.
Mol Microbiol. 2004 Oct;54(2):291-7. doi: 10.1111/j.1365-2958.2004.04276.x.
Whereas the importance of calcium as a cell regulator is well established in eukaryotes, the role of calcium in prokaryotes is still elusive. Over the past few years, there has been an increased interest in the role of calcium in bacteria. It has been demonstrated that as in eukaryotic organisms, the intracellular calcium concentration in prokaryotes is tightly regulated ranging from 100 to 300 nM. It has been found that calcium ions are involved in the maintenance of cell structure, motility, transport and cell differentiation processes such as sporulation, heterocyst formation and fruiting body development. In addition, a number of calcium-binding proteins have been isolated in several prokaryotic organisms. The characterization of these proteins and the identification of other factors suggest the possibility that calcium signal transduction exists in bacteria. This review presents recent developments of calcium in bacteria as it relates to signal transduction.
虽然钙作为细胞调节剂在真核生物中的重要性已得到充分证实，但钙在原核生物中的作用仍不明确。在过去几年中，人们对钙在细菌中的作用越来越感兴趣。已经证明，与真核生物一样，原核生物细胞内的钙浓度受到严格调节，范围在100至300 nM之间。已经发现钙离子参与细胞结构的维持、运动性、运输以及细胞分化过程，如孢子形成、异形胞形成和子实体发育。此外，在几种原核生物中已分离出多种钙结合蛋白。这些蛋白质的特性以及其他因素的鉴定表明细菌中存在钙信号转导的可能性。本综述介绍了与信号转导相关的细菌中钙的最新研究进展。
