García García María L, Calvo Rey C, Martín del Valle F, López Huertas M R, Casas Flecha I, Díaz-Delgado R, Pérez-Breña P
Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, Spain.
An Pediatr (Barc). 2004 Sep;61(3):213-8. doi: 10.1016/s1695-4033(04)78799-8.
Human metapneumovirus (hPMV) is a recently identified virus that is recognized as a cause of respiratory tract illness in the pediatric population.
To determine the incidence of respiratory tract infections caused by hPMV in hospitalized infants and to describe the clinical characteristics and possible presence of coinfection with other viral agents.
We performed a prospective study from September to June 2003 in all children aged less than 24 months who were admitted to the Severo Ochoa Hospital (Leganés, Madrid) with a respiratory tract infection. Virological diagnosis was made with a direct immunofluorescent assay and/or reverse transcriptase-polymerase chain reaction on specimens obtained from nasopharyngeal washing. Demographic and clinical data from patients with an hPMV respiratory tract infection were analyzed.
During the study period, 200 infants were admitted with a respiratory tract infection, of which 18 (9 %) had an hPMV infection. HPMV was the viral agent isolated in 13.8 % of positive nasopharyngeal washings. All patients were admitted between March and April. The mean age was 6.7 +/- 6.1 months. The most common diagnoses were recurrent wheezing (55.5 %) and bronchiolitis (38.8 %). Oxygen therapy was required by 55.5 % of infants during hospitalization. Coinfection with other respiratory viruses was confirmed in 33.3 % of the patients.
Human metapneumovirus is a major cause of respiratory tract illness in hospitalized infants. This virus causes mainly bronchiolitis and recurrent wheezing and is more frequent in spring. Coinfection with other respiratory viruses is frequent.
人偏肺病毒（hPMV）是一种最近发现的病毒，被认为是引起儿科人群呼吸道疾病的病因。
确定住院婴儿中由hPMV引起的呼吸道感染的发病率，并描述其临床特征以及与其他病毒病原体合并感染的可能情况。
我们于2003年9月至2006年6月对所有入住塞韦罗·奥乔亚医院（马德里莱加内斯）的年龄小于24个月且患有呼吸道感染的儿童进行了一项前瞻性研究。通过对从鼻咽冲洗液中获取的标本进行直接免疫荧光测定和/或逆转录聚合酶链反应进行病毒学诊断。对患有hPMV呼吸道感染的患者的人口统计学和临床数据进行了分析。
在研究期间，200名婴儿因呼吸道感染入院，其中18名（9%）患有hPMV感染。hPMV是在13.8%的阳性鼻咽冲洗液中分离出的病毒病原体。所有患者均在3月和4月入院。平均年龄为6.7±6.1个月。最常见的诊断是反复喘息（55.5%）和细支气管炎（38.8%）。55.5%的婴儿在住院期间需要吸氧治疗。33.3%的患者被证实与其他呼吸道病毒合并感染。
人偏肺病毒是住院婴儿呼吸道疾病的主要病因。这种病毒主要引起细支气管炎和反复喘息，在春季更为常见。与其他呼吸道病毒合并感染很常见。
