Buyukyazi G, Kutukculer N, Kutlu N, Genel F, Karadeniz G, Ozkutuk N
School of Physical Education and Sports, Celal Bayar University , Manisa, Turkey.
J Sports Med Phys Fitness. 2004 Jun;44(2):207-14.
The effects of acute exercise on immune system and serum magnesium and iron have been investigated in recent years. However, data related to the comparisons of long-term physical training with different intensity and duration are limited.
The association between long-term physical training and cellular (lymphocyte phenotyping) and humoral immune parameters (serum immunoglobulins) and serum magnesium and iron values in the middle-aged men was investigated. Eleven male master athletes (MA) performing high intensity and long duration training, 11 male recreational athletes (RA) performing moderate intensity and duration training (>10 years) participated. Eleven male sedentary individuals were enrolled as control group (CG).
The percentages of total CD3+ T cells, CD4+ T helper, CD8+ T suppressor/cytotoxic, CD19+ B cells, natural killer cells, HLA-DR+ active T cells and CD4/CD8 ratios did not show any significant difference among 3 groups. In MA, VO2max values showed a significant negative correlation with CD4+ T helper cells. There were no significant differences among MA, RA and CG in terms of IgG, IgA, and IgM concentrations. There was a significant correlation between VO2max and IgG in RA. Iron, iron binding capacity and ferritin were found similar in all groups, but serum magnesium level in MA was significantly lower than RA and CG.
No exact data to support immunosuppression or immunostimulation could be obtained except a significant negative correlation between CD4+ T helper cells and VO2max values in MA and a positive correlation between serum IgG and VO2max ivalues in RA. These findings may be the indirect markers of cellular immune system suppression by intensive exercises and stimulation of IgG production by moderate exercises.
近年来已对急性运动对免疫系统以及血清镁和铁的影响进行了研究。然而，关于不同强度和持续时间的长期体育锻炼比较的数据有限。
研究了中年男性长期体育锻炼与细胞免疫参数（淋巴细胞表型分析）、体液免疫参数（血清免疫球蛋白）以及血清镁和铁值之间的关联。11名进行高强度和长时间训练的男性大师级运动员（MA）、11名进行中等强度和持续时间训练（超过10年）的男性休闲运动员（RA）参与其中。招募了11名久坐不动的男性作为对照组（CG）。
3组之间总CD3 + T细胞、CD4 +辅助性T细胞、CD8 +抑制性/细胞毒性T细胞、CD19 + B细胞、自然杀伤细胞、HLA - DR +活化T细胞的百分比以及CD4/CD8比值均未显示出任何显著差异。在MA组中，最大摄氧量（VO2max）值与CD4 +辅助性T细胞呈显著负相关。MA组、RA组和CG组在IgG、IgA和IgM浓度方面无显著差异。RA组中VO2max与IgG之间存在显著相关性。所有组的铁、铁结合能力和铁蛋白相似，但MA组的血清镁水平显著低于RA组和CG组。
除了MA组中CD4 +辅助性T细胞与VO2max值之间存在显著负相关以及RA组中血清IgG与VO2max值之间存在正相关外，未获得支持免疫抑制或免疫刺激的确切数据。这些发现可能是高强度运动抑制细胞免疫系统以及中等强度运动刺激IgG产生的间接指标。
