Lawrence Victor J, Kopelman Peter G
Queen Mary's School of Medicine and Dentistry, University of London, London, UK.
Clin Dermatol. 2004 Jul-Aug;22(4):296-302. doi: 10.1016/j.clindermatol.2004.01.012.
The obese are subject to health problems directly relating to the carriage of excess adipose tissue. These problems range from arthritis, aches and pains, sleep disturbance, dyspnea on mild exertion, and excessive sweating to social stigmatization and discrimination, all of which may contribute to low quality of life and depression (Table 1). The most serious medical consequences of obesity are a result of endocrine and metabolic changes, most notably type 2 diabetes mellitus, cardiovascular disease, and increased risk of cancer. Not all obesity comorbidities are fully reversed by weight loss. The degree and duration of weight loss required may not be achievable by an individual patient. Furthermore, "weight cycling" may be more detrimental to both physical and mental health than failure to achieve weight loss targets with medical and lifestyle advice.
肥胖者容易出现与携带过多脂肪组织直接相关的健康问题。这些问题包括关节炎、疼痛、睡眠障碍、轻度运动时呼吸困难、多汗，以及社会污名化和歧视，所有这些都可能导致生活质量低下和抑郁（表1）。肥胖最严重的医学后果是内分泌和代谢变化的结果，最显著的是2型糖尿病、心血管疾病和癌症风险增加。并非所有肥胖合并症都能通过减肥完全逆转。个体患者可能无法达到所需的减肥程度和持续时间。此外，与按照医学和生活方式建议未能达到减肥目标相比，“体重循环”可能对身心健康更有害。
