Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
J Nat Prod. 2008 Nov;71(11):1866-71. doi: 10.1021/np8003694. Epub 2008 Oct 30.
Ten new sesterterpene compounds (4-13) and seven known metabolites (1-3, 14-17) were isolated from the sponge Smenospongia sp. collected from Korean coastal waters. On the basis of combined spectroscopic analyses, the new compounds exhibited diverse functionalities on a common scalarane sesterterpene structure. The presence of a 23-aldehyde on compound 6 and a 20-carboxylic acid on 11 is unprecedented among sponge-derived scalarane sesterterpenes. Several of the new compounds showed significant cytotoxicity and antimicrobial activity, as well as moderate inhibitory activity against isocitrate lyase.
从韩国沿海水域采集的海绵 Smenospongia sp. 中分离得到了 10 种新的甾体化合物（4-13）和 7 种已知代谢物（1-3、14-17）。基于综合光谱分析，这些新化合物在常见的海兔烷甾体结构上表现出不同的功能。化合物 6 中存在 23-醛基和 11 中存在 20-羧酸基在海绵衍生的海兔烷甾体中是前所未有的。其中一些新化合物表现出显著的细胞毒性和抗菌活性，以及对异柠檬酸裂解酶的中等抑制活性。
