Preparatory Year Program, Department of Chemistry, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Molecules. 2022 Sep 14;27(18):5969. doi: 10.3390/molecules27185969.
Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolites with unique and unusual chemical skeletons, including terpenoids (sesqui-, di-, and sesterterpenoids), indole alkaloids, aplysinopsins, bisspiroimidazolidinones, chromenes, γ-pyrones, phenyl alkenes, naphthoquinones, and polyketides that possessed diversified bioactivities. This review provided an overview of the reported metabolites from sponges, including their biosynthesis, synthesis, and bioactivities in the period from 1980 to June 2022. The structural characteristics and diverse bioactivities of these metabolites could attract a great deal of attention from natural-product chemists and pharmaceuticals seeking to develop these metabolites into medicine for the treatment and prevention of certain health concerns.
海洋海绵继续引起人们的极大关注，是海洋环境中生物活性代谢产物最丰富的来源之一。（目：Dictyoceratida，科：Thorectidae）属海绵可以产生具有独特和不寻常化学骨架的多种代谢产物，包括萜类（倍半萜、二萜和倍半萜）、吲哚生物碱、aplysinopsins、双螺环咪唑烷酮、色烯、γ-吡喃酮、苯乙烯、萘醌和聚酮，具有多样化的生物活性。本综述概述了 1980 年至 2022 年 6 月期间从 海绵中报道的代谢产物，包括它们的生物合成、合成和生物活性。这些代谢产物的结构特征和多样化的生物活性可能会引起天然产物化学家以及制药行业的极大关注，他们希望将这些代谢产物开发成用于治疗和预防某些健康问题的药物。
