Donath K, Laass M, Günzl H J
Department of Oral Pathology, University of Hamburg, Federal Republic of Germany.
Virchows Arch A Pathol Anat Histopathol. 1992;420(2):131-7. doi: 10.1007/BF02358804.
Foreign bodies may be endogenous or exogenous and provoke chronic inflammation of the foreign-body type. The reaction provides a mechanism for elimination of the foreign body and the reaction pattern depends on the kind of tissue involved. In soft tissues there is cellular inflammation and fibrous encapsulation with macrophages. In bone, during the healing period, biomechanical factors determine whether a fibrous encapsulation or a bony covering develops demarcating the foreign material. The particular characteristics of the foreign-body reaction in bone explain the success of dental and orthopaedic implants.
异物可以是内源性的或外源性的，并引发异物型慢性炎症。这种反应提供了一种清除异物的机制，反应模式取决于所涉及的组织类型。在软组织中，会出现细胞炎症以及巨噬细胞介导的纤维包裹。在骨组织中，在愈合期，生物力学因素决定是形成纤维包裹还是形成界定异物的骨覆盖物。骨组织中异物反应的特殊特征解释了牙科和骨科植入物的成功原因。
