The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces.

The results of a research project which has been under way for the last 7 years are reported. The project has been centred around a series of animal (monkey) experiments designed to test the suitability of cylindrical titanium implants with titanium-sprayed surfaces. The following results have been obtained: 1. The bone applies itself "ankylotically" (i.e. without an intervening layer of connective tissue) to the surface of the implant and, as revealed by observation over periods of up to 1 3/4 years, even remains attached to the implant surface when placed under load. 2. The fibres of the connective tissue between the bone and the epithelium insert into the titanium-sprayed surface and appear to be functionally orientated. 3. If the post of the implant is situated in a region of immobile, keratinized mucosa signs of adhesion of the epithelial cells to the titanium-sprayed surface become apparent. 4. The clinical success of the implant is clearly dependent on (a) the presence of tethered, immobile mucosa ("gingiva") around the post of the implant, and (b) perfect oral hygiene.