Ovington Liza G
Ovington & Associates, Inc., Miami, Fla., USA.
Ostomy Wound Manage. 2004 Sep;50(9A Suppl):1S-10S.
Interest in silver as a topical agent in wound healing is undergoing a renaissance. Having basic information regarding silver's chemical properties and potential actions in the wound bed is important to its appropriate clinical use. Such information is also relevant to the interpretation of silver's in vitro antimicrobial (antiseptic) effects, which in turn relate to issues involved in the evaluation of the clinical effects of silver in vivo. Gaining an understanding of the basic science of silver products and the different challenges inherent to in vitro versus in vivo antimicrobial evaluations will allow clinicians to address several key questions inherent when considering the use of silver as a topical antimicrobial: 1) Are there different forms of silver? 2) How does the amount of silver released into the wound environment correlate with clinical benefit? 3) How does the rate of silver release correlate with clinical benefit?
人们对银作为伤口愈合局部用药的兴趣正在复兴。掌握银的化学性质及其在伤口床中的潜在作用的基本信息，对于其在临床中的合理应用至关重要。这些信息对于解释银的体外抗菌（防腐）作用也很重要，而这又与评估银在体内的临床效果所涉及的问题相关。了解银产品的基础科学以及体外与体内抗菌评估所固有的不同挑战，将使临床医生能够解决在考虑使用银作为局部抗菌剂时所固有的几个关键问题：1）银有不同的形式吗？2）释放到伤口环境中的银量与临床益处如何相关？3）银的释放速率与临床益处如何相关？
