Davis C D, Greger J L
Department of Nutritional Sciences, University of Wisconsin, Madison.
Am J Clin Nutr. 1992 Mar;55(3):747-52. doi: 10.1093/ajcn/55.3.747.
The effect of dietary factors on manganese-dependent superoxide dismutase (MnSOD) activity in humans has not been studied. We longitudinally evaluated changes in MnSOD activity and other indices of manganese and iron status in 47 women during a 124-d supplementation study. Subjects received one of four treatments: placebo, 60 mg iron, 15 mg manganese, or both mineral supplements daily. Manganese supplementation resulted in significant increases in lymphocyte MnSOD activity and serum manganese concentrations from baseline values but no changes in urinary manganese excretion or in any indices of iron status. Oral contraceptive use and the stage of the menstrual cycle did not confound the use of lymphocyte MnSOD activity or serum manganese to monitor manganese status, but fat intake affected both indices. This work demonstrated that lymphocyte MnSOD activity can be used with serum manganese concentrations to monitor manganese exposure in humans.
饮食因素对人体锰依赖性超氧化物歧化酶（MnSOD）活性的影响尚未得到研究。在一项为期124天的补充研究中，我们纵向评估了47名女性的MnSOD活性变化以及锰和铁状态的其他指标。受试者每天接受四种治疗之一：安慰剂、60毫克铁、15毫克锰或两种矿物质补充剂。补充锰导致淋巴细胞MnSOD活性和血清锰浓度相对于基线值显著增加，但尿锰排泄或任何铁状态指标均无变化。口服避孕药的使用和月经周期阶段并未混淆使用淋巴细胞MnSOD活性或血清锰来监测锰状态，但脂肪摄入量影响了这两个指标。这项研究表明，淋巴细胞MnSOD活性可与血清锰浓度一起用于监测人体的锰暴露情况。
