Mata P, Alvarez-Sala L A, Rubio M J, Nuño J, De Oya M
Department of Internal Medicine, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.
Am J Clin Nutr. 1992 Apr;55(4):846-50. doi: 10.1093/ajcn/55.4.846.
The effect of dietary-fat saturation on plasma lipoprotein concentrations was assessed in 46 men and 32 women placed on a diet enriched in polyunsaturated fatty acids (sunflower oil) for 12 wk and, under isocaloric conditions, on a diet enriched in monounsaturated fatty acids (olive oil) for the next 16 wk in men and 28 wk in women. Fat comprised 37% of the total energy intake in men and 36% in women. At the end of the monounsaturated fatty acid diet no change occurred in total cholesterol (TC) in men but it increased by 9% in women. High-density-lipoprotein (HDL) cholesterol increased by 17% in men and by 30% in women. The atherogenic index (TC:HDL cholesterol) fell significantly in both sexes. No significant changes occurred in plasma low-density-lipoprotein cholesterol or in total triglycerides values. These data show that when compared with polyunsaturates, monounsaturates increased HDL cholesterol and reduced the atherogenic risk profile in both sexes.
对46名男性和32名女性进行了研究，评估膳食脂肪饱和度对血浆脂蛋白浓度的影响。这些受试者先食用富含多不饱和脂肪酸（葵花籽油）的饮食12周，然后在等热量条件下，男性接下来的16周和女性接下来的28周食用富含单不饱和脂肪酸（橄榄油）的饮食。脂肪在男性总能量摄入中占37%，在女性中占36%。在单不饱和脂肪酸饮食结束时，男性的总胆固醇（TC）没有变化，但女性的总胆固醇增加了9%。高密度脂蛋白（HDL）胆固醇在男性中增加了17%，在女性中增加了30%。动脉粥样硬化指数（TC:HDL胆固醇）在两性中均显著下降。血浆低密度脂蛋白胆固醇或总甘油三酯值没有显著变化。这些数据表明，与多不饱和脂肪酸相比，单不饱和脂肪酸可增加两性的HDL胆固醇并降低动脉粥样硬化风险。
