Swanson J E, Laine D C, Thomas W, Bantle J P
Department of Medicine, School of Public Health, University of Minnesota, Minneapolis.
Am J Clin Nutr. 1992 Apr;55(4):851-6. doi: 10.1093/ajcn/55.4.851.
To determine if dietary fructose causes adverse metabolic effects, we used a crossover design to compare a diet containing 20% of energy from fructose with an isoenergic high-starch diet that contained less than 3% fructose. Fourteen healthy subjects consumed each diet for 28 d. There were no significant differences between the diets in the mean values of hemoglobin A1C, serum glycosylated albumin, fasting plasma glucose, peak postprandial plasma glucose, integrated plasma glucose, fasting serum lactate, or fasting serum triglycerides. Peak postprandial serum lactate was significantly higher during the fructose diet at days 1, 7, and 14 but not at days 21 or 28. Peak postprandial serum triglycerides were significantly higher only at day 1 of the fructose diet. Day-28 fasting serum total and LDL cholesterol for the fructose diet were 9.0% and 11.0% higher, respectively, than the corresponding values for the starch diet. A high-fructose diet compared with a high-starch diet resulted in significantly higher fasting serum total and LDL cholesterol and also caused transient changes in postprandial serum lactate and triglycerides.
为了确定膳食果糖是否会引起不良代谢效应，我们采用交叉设计，将含20%能量来自果糖的饮食与含能量相等但果糖含量低于3%的高淀粉饮食进行比较。14名健康受试者分别食用每种饮食28天。两种饮食在糖化血红蛋白A1C、血清糖化白蛋白、空腹血糖、餐后血糖峰值、血糖整合值、空腹血清乳酸或空腹血清甘油三酯的平均值方面无显著差异。餐后血清乳酸峰值在果糖饮食的第1天、第7天和第14天显著高于高淀粉饮食，但在第21天或第28天并非如此。餐后血清甘油三酯峰值仅在果糖饮食的第1天显著高于高淀粉饮食。果糖饮食的第28天空腹血清总胆固醇和低密度脂蛋白胆固醇分别比淀粉饮食的相应值高9.0%和11.0%。与高淀粉饮食相比，高果糖饮食导致空腹血清总胆固醇和低密度脂蛋白胆固醇显著升高，还引起餐后血清乳酸和甘油三酯的短暂变化。
