[吸烟对狼疮患者皮肤病变抗疟药疗效的影响：一项前瞻性研究评估]
[Effect of smoking on the effectiveness of antimalarial drugs for cutaneous lesions of patients with lupus: assessment in a prospective study].
作者信息
Lardet D, Martin S, Truchetet F, Cuny J F, Virion J M, Schmutz J L
机构信息
Service de dermatologie, hôpital Fournier, CHU de Nancy, 36, quai de la bataille, 54000 Nancy, France.
出版信息
Rev Med Interne. 2004 Nov;25(11):786-91. doi: 10.1016/j.revmed.2004.07.005.
PURPOSE
Smoking has been involved in the failure of antimalarial therapy in patient with chronic or subacute erythematosus lupus.
METHODS
We report a prospective study of 26 patients with chronic, subacute or systemic erythematosus lupus who were treated with antimalarials. Several variables including smoking are compared in responders and non-responders.
RESULTS
Despite the reduced number of patients study that does not permit to allow significative results, it seems that among responders and non-responders, in other respects comparables, there is no difference in the presence of smoking, its quantity or its duration.
CONCLUSION
The significance of molecular interactions between some components of tobacco and antimalarials have still to be established.
目的
吸烟与慢性或亚急性红斑狼疮患者抗疟治疗失败有关。
方法
我们报告了一项对26例接受抗疟药治疗的慢性、亚急性或系统性红斑狼疮患者的前瞻性研究。比较了包括吸烟在内的几个变量在反应者和无反应者中的情况。
结果
尽管研究患者数量减少，无法得出有意义的结果，但在反应者和无反应者中（在其他方面具有可比性），吸烟情况、吸烟量或吸烟持续时间似乎没有差异。
结论
烟草某些成分与抗疟药之间分子相互作用的意义仍有待确定。
Zotero 插件