鞭毛蛋白的黏膜给药可诱导小鼠肺部的天然免疫。
Mucosal administration of flagellin induces innate immunity in the mouse lung.
作者信息
Honko Anna N, Mizel Steven B
机构信息
Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
出版信息
Infect Immun. 2004 Nov;72(11):6676-9. doi: 10.1128/IAI.72.11.6676-6679.2004.
Abstract
Nonsurgical intratracheal instillation of 1 microg of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1alpha, and MIP-2.
摘要
在数种小鼠品系中，通过非手术方式经气管内注入1微克纯化的重组鞭毛蛋白，可刺激肺部产生短暂的先天性免疫反应，其特征为中性粒细胞浸润以及肿瘤坏死因子α、白细胞介素6、粒细胞集落刺激因子和趋化因子角质形成细胞衍生趋化因子、巨噬细胞炎性蛋白1α和巨噬细胞炎性蛋白-2的快速产生。
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