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鞭毛蛋白的黏膜给药可诱导小鼠肺部的天然免疫。

Mucosal administration of flagellin induces innate immunity in the mouse lung.

作者信息

Honko Anna N, Mizel Steven B

机构信息

Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.

出版信息

Infect Immun. 2004 Nov;72(11):6676-9. doi: 10.1128/IAI.72.11.6676-6679.2004.

DOI:10.1128/IAI.72.11.6676-6679.2004
PMID:15501801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC523048/
Abstract

Nonsurgical intratracheal instillation of 1 microg of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1alpha, and MIP-2.

摘要

在数种小鼠品系中，通过非手术方式经气管内注入1微克纯化的重组鞭毛蛋白，可刺激肺部产生短暂的先天性免疫反应，其特征为中性粒细胞浸润以及肿瘤坏死因子α、白细胞介素6、粒细胞集落刺激因子和趋化因子角质形成细胞衍生趋化因子、巨噬细胞炎性蛋白1α和巨噬细胞炎性蛋白-2的快速产生。

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Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6664-8. doi: 10.1073/pnas.0307553101. Epub 2004 Apr 14.
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Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella.鞭毛蛋白是肠致病性沙门氏菌的主要促炎决定因素。
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Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.革兰氏阴性菌鞭毛蛋白诱导巨噬细胞产生一氧化氮涉及通过异源三聚体Toll样受体5/Toll样受体4复合物进行信号传导。
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