Hamamoto K, Yoshioka A, Taniguchi H, Ohaga S, Nagano T, Kishimoto Y, Kitajima H, Fujimoto M, Kimura T, Fujitake H
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Cancer Genet Cytogenet. 1992 Feb;58(2):130-3. doi: 10.1016/0165-4608(92)90098-s.
We report an 82-year-old Japanese female with acute myelomonocytic leukemia with dysplastic marrow eosinophilia (FAB M4Eo) exhibiting a partial deletion of the long arm of chromosome 5, del(5)(q13q31) and a derivative chromosome 16 with a breakpoint at band 16q22, in addition to 5q-. The patient had a history of a preleukemic phase for several months with marked dysplasia in trilineage marrow cells, in addition to leukemic features compatible with M4Eo. These findings strongly suggested that the leukemic cells in this case were derived from a preleukemic clone with a del(5q).
我们报告了一名82岁的日本女性，患有急性粒单核细胞白血病伴骨髓嗜酸性粒细胞发育异常（FAB M4Eo），除了5q-外，还表现出5号染色体长臂部分缺失，即del(5)(q13q31)，以及一条16号衍生染色体，其断点位于16q22带。该患者有几个月的白血病前期病史，除了具有与M4Eo相符的白血病特征外，三系骨髓细胞还存在明显发育异常。这些发现强烈提示，该病例中的白血病细胞源自一个具有del(5q)的白血病前期克隆。
