Davidovitz Y, Zimlichman R, Rosner E, Berkowic M, Ballin A, Meytes D
Department of Hematology and Internal Medicine (F), Edith Wolfson Medical Center, Holon, Israel.
Cancer Genet Cytogenet. 1997 Sep;97(2):122-4. doi: 10.1016/s0165-4608(96)00391-3.
We report a 62-year-old man with acute myelomonocytic leukemia with bone marrow eosinophilia (M4Eo), and a deletion of the long arm of chromosome 7. The patient presented with pancytopenia, which shortly after evolved to overt leukemia. There was no response to the daunorubicin-cytosine arabinoside (Ara-C) regimen, and a remission achieved with amsacrine (AMSA)-Ara-C lasted only for a short time. On relapse, a peculiar skin rash accompanied the hematologic picture. While ANLL with chromosome 7 abnormalities usually carries adverse prognosis, patients with M4Eo (which is usually associated with chromosome 16 abnormalities) do better. The patient described here examplifies that M4Eo may be associated with del(7)(q22), and that it is the chromosomal abnormality rather than the type of leukemia that might determine the clinical outcome.
我们报告了一名62岁男性，患有急性粒单核细胞白血病伴骨髓嗜酸性粒细胞增多（M4Eo），且存在7号染色体长臂缺失。患者最初表现为全血细胞减少，不久后发展为明显的白血病。患者对柔红霉素 - 阿糖胞苷（Ara - C）方案无反应，而使用安吖啶（AMSA） - Ara - C达到的缓解仅持续了很短时间。复发时，血液学表现伴有一种特殊的皮疹。虽然伴有7号染色体异常的急性非淋巴细胞白血病（ANLL）通常预后不良，但M4Eo患者（通常与16号染色体异常相关）预后较好。此处描述的患者表明M4Eo可能与del(7)(q22)相关，并且可能是染色体异常而非白血病类型决定临床结果。
