Yapp R, Modlin I M, Kumar R R, Binder H J, Dubrow R
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510.
Dig Dis Sci. 1992 Apr;37(4):481-4. doi: 10.1007/BF01307566.
Plasma gastrin has been reported to be elevated among patients with colorectal cancer. The objectives of the present study were to confirm this observation and, if confirmed, to shed light on the reason for the elevation. Presurgical and postsurgical fasting plasma gastrin levels were compared between 24 patients hospitalized for colorectal adenocarcinoma resection and 25 control patients hospitalized for other surgery. Elevated presurgical gastrin levels in the case group that fell after surgery would be consistent with production of gastrin by the tumor. High presurgical gastrin levels in the case group that did not change following surgery would be consistent with excess gastrin production by G cells. The mean presurgical gastrin levels were 21.9 +/- 3.7 pM (cases) and 45.1 +/- 18.0 pM (controls). The mean postsurgical gastrin levels were 20.5 +/- 3.9 pM (cases) and 43.4 +/- 14.6 pM (controls). These results do not provide support for the hypotheses that gastrin is elevated in colorectal cancer patients or that gastrin is secreted by colorectal tumors in sufficient quantities to be measurable in the plasma.
据报道，血浆胃泌素在结直肠癌患者中升高。本研究的目的是证实这一观察结果，如果得到证实，则阐明其升高的原因。比较了24例因结肠腺癌切除术住院的患者和25例因其他手术住院的对照患者术前和术后的空腹血浆胃泌素水平。病例组术前胃泌素水平升高且术后下降，这与肿瘤产生胃泌素一致。病例组术前胃泌素水平高且术后未改变，这与G细胞产生过量胃泌素一致。术前胃泌素平均水平为21.9±3.7 pM（病例组）和45.1±18.0 pM（对照组）。术后胃泌素平均水平为20.5±3.9 pM（病例组）和43.4±14.6 pM（对照组）。这些结果不支持结直肠癌患者胃泌素升高或结直肠肿瘤分泌足够量的胃泌素以至于在血浆中可测量的假说。
