Tatsuta M, Iishi H, Yamamura H, Taniguchi H
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Int J Cancer. 1988 Feb 15;41(2):239-42. doi: 10.1002/ijc.2910410214.
The effect of dietary wheat bran consumption on the anticarcinogenic action of tetragastrin upon colon carcinogenesis induced by azoxymethane was investigated in 122 inbred Wistar rats. Rats were given a control fiber-free diet or the same basal diet plus 20% wheat bran. From week 5, they were given 250 micrograms per kg body weight of tetragastrin in depot form every other day until the end of the experiment at week 45. Prolonged administration of tetragastrin resulted in a significant reduction of the incidence and number of colonic tumors per rat in the group given the fiber-free diet. The adenocarcinomas that did develop in this group had high mucin-producing activity, unlike the cancers produced in controls without tetragastrin. However, administration of tetragastrin had little or no influence on the incidence, number or histology of colonic tumors in the group given basal diet plus wheat bran. Dietary supplementation with wheat bran alone had little or no effect on the development or histology of colonic tumors. Before and during the administration of carcinogens, addition of fiber to the diet resulted in a significant fall in the colonic pH and a significant increase in the crypt column length, but administration of tetragastrin did not have an additive effect on the crypt column length in rats fed diet supplemented with fiber.
在122只近交系Wistar大鼠中，研究了食用麦麸对四肽胃泌素在由氧化偶氮甲烷诱导的结肠癌发生过程中的抗癌作用的影响。给大鼠喂食无纤维对照饮食或相同的基础饮食加20%的麦麸。从第5周开始，每隔一天给它们皮下注射每千克体重250微克的四肽胃泌素，直到第45周实验结束。在喂食无纤维饮食的组中，长期给予四肽胃泌素导致每只大鼠结肠肿瘤的发生率和数量显著降低。与未接受四肽胃泌素的对照组所产生的癌症不同，该组中确实发生的腺癌具有高黏液分泌活性。然而，给予四肽胃泌素对喂食基础饮食加麦麸的组中结肠肿瘤的发生率、数量或组织学几乎没有影响。单独补充麦麸对结肠肿瘤的发生或组织学几乎没有影响。在给予致癌物之前和期间，在饮食中添加纤维导致结肠pH值显著下降和隐窝柱长度显著增加，但给予四肽胃泌素对喂食添加纤维饮食的大鼠的隐窝柱长度没有叠加作用。
